We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association of thyroglobulin gene variants with carcass and meat quality traits in beef cattle.
- Authors
Hou, Guan-Yu; Yuan, Zheng-Rong; Zhou, Han-Lin; Zhang, Lu-Pei; Li, Jun-Ya; Gao, Xue; Wang, Dong-Jing; Gao, Hui-Jiang; Xu, Shang-Zhong
- Abstract
Thyroid hormones play an important role in regulating metabolism and can affect homeostasis of fat deposition. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. In the present study, we identified 6 novel SNPs at the 3′ flanking region of the TG gene. The SNP marker association analysis indicated that the T354C, G392A, A430G and T433G SNP markers were significantly associated with marbling score ( P < 0.05). Animals with the new homozygote genotype had higher marbling score than those with the other genotypes. Otherwise, the linkage disequilibrium analysis indicated that these four SNPs were completely linked ( r = 1). Results from this study suggest that TG gene-specific SNP may be a useful marker for meat quality traits in future marker assisted selection programs in beef cattle.
- Subjects
THYROID hormones; HORMONES; THYROID gland; THYROGLOBULIN; CATTLE; BEEF cattle
- Publication
Molecular Biology Reports, 2011, Vol 38, Issue 7, p4705
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-010-0605-1