We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Induction of cytotoxicity by photoexcitation of TiO can prolong survival in glioma-bearing mice.
- Authors
Chao Wang; Shouqiang Cao; Xinxin Tie; Bo Qiu; Anhua Wu; Zhihong Zheng
- Abstract
We have investigated the possibility that photoexcited titanium dioxide (TiO) could inhibit the growth of malignant cells. We studied the anti-glioma effects of nano-TiO excited with ultraviolet A (UVA) irradiation both in vitro and in vivo. Transmission electron microscopy demonstrated that glioma cells take up TiO by phagocytosis, and vital staining revealed that TiO alone has no effect on glioma cell proliferation. However, if TiO was combined with UVA irradiation the proliferation rate was decreased significantly compared to controls ( P < 0.05). RT-PCR suggested that TiO induction of glioma cell apoptosis is associated with changes in the expression of genes encoding Bcl-2 family members. We then investigated the in vivo antitumor effects of combined TiO plus UVA treatment of established glioma tumors. TiO plus UVA led to pronounced areas of necrosis, elevated indices of apoptosis, delayed tumor growth, and increased survival compared with the TiO-alone control group ( P < 0.001). Log-rank survival analysis showed that median survival duration was prolonged ( P < 0.001). These findings suggest that nano-TiO based photodynamic therapy has potential in the treatment of glioma.
- Publication
Molecular Biology Reports, 2011, Vol 38, Issue 1, p523
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-010-0136-9