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- Title
Cognitive function in cancer survivors: analysis of the 1999-2002 National Health and Nutrition Examination Survey.
- Authors
Williams, A.; Janelsins, M.; Wijngaarden, E.; Williams, A M; Janelsins, M C; van Wijngaarden, E
- Abstract
<bold>Purpose: </bold>Cancer and its treatment may affect cognitive function through a number of direct and indirect pathways including inflammation, lipid metabolism, vascular damage, and changes in the blood-brain barrier. While short-term treatment-related cognitive changes are well recognized, only limited research is available in older, long-term survivors of cancer.<bold>Methods: </bold>Using NHANES data from 1999 to 2002, 408 cancer survivors and 2639 non-cancer participants aged 60 years old and above were identified. Cognitive function of these groups were compared using the Digit Symbol Substitution Test (DSST) and self-reported problems with memory or confusion.<bold>Results: </bold>After adjustment for covariates, cancer survivors scored, on average, 1.99 points lower on the DSST compared to non-cancer survivors (-1.99, 95 % CI -3.94, -0.05). Cancer survivors also had 17 % higher odds of self-reporting problems with memory or confusion (OR 1.17, 95 % CI 0.89, 1.53).<bold>Conclusion: </bold>In this nationally representative sample of older US adults, cancer survivors had lower DSST scores than non-survivors and had more self-reported problems with memory or confusion.
- Subjects
CANCER patient psychology; COGNITIVE ability; CANCER treatment; MEMORY; HEALTH &; Nutrition Examination Survey; TUMORS &; psychology; COGNITION; QUESTIONNAIRES; RESEARCH funding; SURVEYS; TUMORS; CASE-control method
- Publication
Supportive Care in Cancer, 2016, Vol 24, Issue 5, p2155
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-015-2992-2