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- Title
Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.
- Authors
Schoonjans, Kristina; Annicotte, Jean-Sebastien; Huby, Thierry; Botrugno, Oronza A.; Fayard, Elisabeth; Ueda, Yukihiko; Chapman, John; Auwerx, Johan
- Abstract
The scavenger receptor class B type I (SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDL5), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH-1) and SR-BI are co-expressed in liver and ovary, suggesting that LRH-1 might control the expression of SR-BI in these tissues. LRH-1 induces human and mouse SR-BI promoter activity by binding to an LRH-1 response element in the promoter. Retroviral expression of LRH-1 robustly induces SR-BI, an effect associated with histone H3 acetylation on the SR-BI promoter. The decrease in SR-BI mRNA levels in livers of LRH-11/- animals provides in vivo evidence that LRH-1 regulates SR-BI expression. Our data demonstrate that SR-BI is an LRH-1 target gene and underscore the pivotal role of LRH-1 in reverse cholesterol transport.
- Subjects
LIVER; CHOLESTEROL; OVARIES; RETROVIRUS diseases; MESSENGER RNA; GENES
- Publication
EMBO Reports, 2002, Vol 3, Issue 12, p1181
- ISSN
1469-221X
- Publication type
Article
- DOI
10.1093/embo-reports/kvf238