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- Title
Cardiovascular Function and Exercise Capacity in Childhood Cancer Survivors.
- Authors
Reiner, Barbara; Schmid, Irene; Schulz, Thorsten; Müller, Jan; Hager, Alfred; Hock, Julia; Ewert, Peter; Wolf, Cordula; Oberhoffer-Fritz, Renate; Weil, Jochen
- Abstract
Introduction: Childhood cancer survivors (CCS) might be at high risk of additional chronic diseases due to cardiotoxic side effects. The aim of this study was to analyze long-term side effects of cancer therapy on vascular structure/function, cardiac biomarkers and on physical activity. Methods: In total, 68 asymptomatic patients aged 16–30 years with childhood cancer (diagnosed 10.6 ± 3.9 years ago) were examined from 2015–2020. (Central) blood pressure and pulse wave velocity were registered via the oscillometric method, while carotid intima-media thickness (cIMT) was measured non-invasively by ultrasound. cIMT values of patients were compared to healthy controls (n = 68; aged 22.3 ± 3.5 years). Patients' exercise capacity was recorded. The plasma N-terminal pro-brain natriuretic protein (NTproBNP) and troponin levels were measured as cardiac biomarkers. CCS were categorized in groups with low, moderate and high anthracyclines. Results: No differences were found in cIMT between patients and controls as well as between patients with various anthracycline dosage. Patients with high dose anthracyclines showed a significant lower performance versus patients with moderate dose anthracyclines (84.4% of predicted VO2peak; p = 0.017). A total of 11.6% of CCS had abnormal NTproBNP values which correlated with received anthracycline dosage (p = 0.024; r = 0.343). Conclusion: NTproBNP levels and exercise capacity might be early markers for cardiovascular dysfunction in CCS and should be included in a follow-up protocol, while cIMT and troponin seem not to be adequate parameters.
- Subjects
AEROBIC capacity; CHILDHOOD cancer; CAROTID intima-media thickness; CANCER survivors; ASYMPTOMATIC patients
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 3, p628
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11030628