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- Title
Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels.
- Authors
Gentile, Marco; Iannuzzi, Arcangelo; Giallauria, Francesco; D'Andrea, Antonello; Venturini, Elio; Pacileo, Mario; Covetti, Giuseppe; Panico, Camilla; Mattiello, Amalia; Vitale, Giuseppe; Sarullo, Filippo Maria; Rubba, Paolo; Vigorito, Carlo; Panico, Salvatore; Iannuzzo, Gabriella
- Abstract
Background: atherosclerotic process inexorably advances in patients reaching low-density lipoprotein cholesterol (LDL-C) targets. An attractive hypothesis is that lipoprotein particles (very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL)), could contribute to residual risk. The present study aims to investigate the relationship between carotid intima-media thickness (IMT) and different lipoprotein subfractions in a cohort of healthy postmenopausal women. Methods: 75 postmenopausal women, at LDL-C target levels without overt cardiovascular disease, underwent biochemical analyses (including subfraction assay of plasma lipoproteins) and carotid ultrasound examination. Results: a statistically significant correlation between VLDL and carotid IMT (p < 0.001) was found. No significant correlation was found between carotid IMT and LDL-C (p = 0.179), IDL-C (p = 0.815), high-density lipoprotein (HDL) (p = 0.855), and LDL score (p = 0.240). Moreover, IMT is significantly correlated to LDL particle diameter (p = 0.044). After adjusting for age, systolic blood pressure, body mass index, smoking habits, glucose plasma concentration, and Lipoprotein(a) (Lpa) levels, multivariate analysis showed that women in the third tertile of VLDL-C, compared with those in the first tertile, were significantly associated to the highest IMT (p = 0.04). Conclusions: in this cohort of postmenopausal women, VLDL-C was significantly associated to carotid IMT, independent of main cardiovascular risk factors. These findings pave the way for targeting circulating concentrations of VLDL-C to reduce cardiovascular events in patients with target LDL-C levels.
- Subjects
POSTMENOPAUSE; CAROTID intima-media thickness; BLOOD lipoproteins; CARDIOVASCULAR diseases risk factors; SYSTOLIC blood pressure
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 5, p1422
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9051422