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- Title
Photo-induced graft-versus-host disease.
- Authors
Hardy, Juliette M.; Marguery, Marie‐Claude; Huynh, Anne; Borel, Cécile; Apoil, Pol André; Lamant, Laurence; Tournier, Emilie; Alberto, Chloé; Pauwels, Céline; Thomas, Marianne; Mazereeuw Hautier, Juliette; Paul, Carle; Bulai Livideanu, Cristina
- Abstract
Overlap chronic graft-versus-host disease (GVHD) associates both features of acute and chronic GVHD. Trigger factors for chronic GVHD are unclear. We describe two patients who received allogenic haematopoietic stem-cell transplantation, and who later developed overlap chronic GVHD after sun exposure. Available data from in vivo investigations suggest ultraviolet B radiation (UVB) has a beneficial effect on acute and chronic GVHD. The role of sun irradiation as a trigger for isomorphic cutaneous GVHD has been rarely reported in the literature. Herein, we demonstrate for the first time, using repetitive broadband phototesting, that UVB triggers chronic GVHD.
- Subjects
EFFECT of ultraviolet radiation on skin; HEMATOPOIETIC stem cell transplantation; THERAPEUTIC use of ultraviolet radiation; PHOTOSENSITIVITY disorders; CHRONIC diseases
- Publication
Photodermatology, Photoimmunology & Photomedicine, 2016, Vol 32, Issue 5/6, p291
- ISSN
0905-4383
- Publication type
Article
- DOI
10.1111/phpp.12273