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- Title
Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium Complexes as Inhibitors of MDA-MB-231 Breast Cancer Cells.
- Authors
Barbosa, Marília I. F.; Corrêa, Rodrigo S.; Guedes, Adriana P. M.; Graça, Alex M.; Andrade, Francyelli M.; Leite, Celisnólia M.; Silveira-Lacerda, Elisângela P.; Ellena, Javier; Reis, Henrique V.; Doriguetto, Antônio C.; Batista, Alzir A.
- Abstract
Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6, where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer.
- Subjects
NITROSYL compounds; CANCER cells; TRIPLE-negative breast cancer; BREAST cancer; DIPHENYLPHOSPHINE; CELL migration; ALANINE; PHENYLALANINE
- Publication
Inorganics, 2023, Vol 11, Issue 7, p270
- ISSN
2304-6740
- Publication type
Article
- DOI
10.3390/inorganics11070270