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- Title
PS02.055: IN ESOPHAGEAL ADENOCARCINOMA (EAC) BARRET LIKE AND CARDIO PYLORIC LIKE SUB TYPES ARE DIFFERENTIATED ACCORDING TO MICRORNA (MIRNA) 221 AND 483–3.P EXPRESSION PROFILES.
- Authors
Bonora, Elena; Isidori, Federica; Bozzarelli, Isotta; Lugaresi, Marialuisa; Malvi, Deborah; Räsänen, Jari; Kauppi, Juha; Sala, Claudia; Castellani, Gastone; D'Errico, Antonietta; Fiocca, Roberto; Seri, Marco; Krishnadath, Kausilia; Mattioli, Sandro
- Abstract
Background miRNAs play a key role in cancer development. In esophageal adenocarcinoma (EAC), we analyzed the relationship between miR-221 and 483–3p expression, cancer specific survival, recurrence, their distribution in EAC sub types characterized by the presence/absence of intestinal metaplasia in esophagus (BIM) and stomach (GIM) [BIM + GIM- (Barret's like) and BIM-GIM- (cardio-pyloric like) types]. Methods RNAs was extracted from 39 formalin-embedded surgical specimens (EAC and normal gastric). miRNA221 and miR-483–3p validation with TaqMan MicroRNA Assay was performed and data were normalized using RNU44. Kruskall-Wallis and Mann-Whitney tests were used to study correlations. Results A statistically significant relationship between miRNAs (miR-483–3p P = 0.017; miR-221 P = 0.037) and cancer specific survival and between miR-221 and recurrence (P = 0.043) was detected. miR-221 and miR-483–3p showed a significant decreased expression in the Barret's like group vs Cardio-pyloric-like group (miR-483–3p Kruskall-Wallis test P = 0.009; miR221 Kruskall-Wallis test P = 0.066; miR-483–3p Mann-Whitney test P = 0.002; miR-221 Mann-Whitney test P = 0.047) View large Download slide View large Download slide Conclusion In EAC increase of miR-221 and miR-483 is linked with poor survival and recurrence. Their different distribution patterns, support a biological differentiation of Barret's like versus cardio-pyloric like subtypes. Disclosure All authors have declared no conflicts of interest.
- Subjects
ADENOCARCINOMA
- Publication
Diseases of the Esophagus, 2018, Vol 31, Issue 13, p136
- ISSN
1120-8694
- Publication type
Article
- DOI
10.1093/dote/doy089.PS02.055