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- Title
The Enhancing Effect of Fungal Immunomodulatory Protein-Volvariella Volvacea (FIP-vvo) on Maturation and Function of Mouse Dendritic Cells.
- Authors
Li, Ju-Pi; Lee, Yi-Pang; Ma, Jung-Chein; Liu, Betty-Revon; Hsieh, Nien-Tsu; Chen, Dz-Chi; Chu, Ching-Liang; You, Ren-In
- Abstract
Volvariella volvacea, also known as straw mushroom, is a common edible mushroom in Chinese cuisine. It contains many nutrients for human health. A fungal immunomodulatory protein (FIP) has been isolated from V. volvacea and named FIP-vvo. Although the regulatory effects of many FIPs on immunity have been identified, the impact of FIP-vvo in modulating dendritic cells (DCs), which play a key role to connect the innate and the adaptive immunity, is not known. In this study, we aim to study the effect of FIP-vvo on the DC maturation and function. We found that FIP-vvo slightly increased the generation of CD11c+ bone marrow-derived DC (BMDC). In addition, the surface expression of MHCII was promoted in BMDCs after the treatment of FIP-vvo, suggesting that FIP-vvo induces DC maturation. Furthermore, FIP-vvo enhanced the ability of BMDCs to activate antigen-specific T cell responses in vitro. In the in vivo study, the FIP-vvo treatment facilitated T cell response in lymph nodes. Therefore, for the first time, our data demonstrated that FIP-vvo promoted DC maturation and function and suggested that FIP-vvo could have benefits for human health by enhancing immunity.
- Subjects
EDIBLE mushrooms; FUNGAL proteins; DENDRITIC cells; CHINESE cooking; NATURAL immunity; T cells
- Publication
Life (2075-1729), 2021, Vol 11, Issue 6, p471
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life11060471