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- Title
Anti-idiotype and immunosuppressant treatment of murine lupus.
- Authors
Morland, C.; Michael, J.; Adu, D.; Kizaki, T.; Howie, A. J.; Morgan, A.; Staines, N. A.
- Abstract
The effect of the administration of a xenogeneic anti-idiotype antibody (anti-Id33) to a cross-reactive idiotype (Id33) present on anti-dsDNA antibody was examined in 6-week-old (NZB/NZW) Fl (BWF1) female mice. The administration of anti-Id33 led to a transient reduction in immunoglobulins expressing Id33, followed by a rise at 30 and 34 weeks that was significantly higher than in untreated mice (P < 0.005). Likewise. anti-dsDNA antibody levels were significantly higher at 10 and 18 weeks than in untreated mice (P < 0.01). No differences were seen in survival to 40 weeks, proteinuria or the severity of glomerulonephritis. Concurrent administration orcyclosporin A (CyA) with anti-Id33 markedly ameliorated glomerular injury and proteinuria and improved survival. By contrast, glomerular injury, proteinuria and survival were worse in mice treated with cyclophosphamide plus anti-Id33. compared with untreated mice. Neither CyA nor cyclophosphamide treatment, when given with anti-Id33 altered serum levels of anti-dsDNA. anti-ssDNA or Id33+ immunoglobin, compared with untreated mice. The different effects of Cy A and cyclophosphamide on T lymphocytes and their discrepant effects on glomerular injury when given with anti-Id33 in this model lead us to postulate a role for T lymphocytes in the glomerular injury of BWF1 lupus.
- Subjects
IMMUNOSUPPRESSIVE agents; ANTI-idiotypic antibodies; IMMUNOGLOBULINS; LYMPHOCYTES; PROTEINURIA; MURIDAE
- Publication
Clinical & Experimental Immunology, 1991, Vol 83, Issue 1, p126
- ISSN
0009-9104
- Publication type
Article