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- Title
Synergy in antigen presentation by thyroid epithelial cells and monocytes from patients with Graves' disease.
- Authors
Eguchi, K.; T. Otsubo; Kawabe, Y.; Shimomura, Chikako; Ueki, Y.; Nakao, H.; Tezuka, H.; Matsunaga, Mayumi; Fukuda, T.; Ishikawa, N.; Ito, K.; Nagataki, S.
- Abstract
The present study was undertaken to examine the ability of thyrocytes from Graves' patients to present purified protein derivative (PPD) to autologous peripheral blood T cells. Normal human thyrocytes which were pre-cultured with interferon-γ were able to induce the proliferation of T cells in response to PPD antigen, but unstimulated thyrocytes failed to do. Thyrocytes from Graves' patients on which HLA-DR antigens were expressed have an ability to induce the proliferation of T cells. Thyrocytes from Graves' patients which were pulsed with PPD antigen for 4 h were capable of stimulating proliferation of the T cells. However, the stimulation index of T cells co-cultured with thyrocytes and PPD were significantly lower than that of T cells co-cultured with monocytes and PPD. Sub-optimal numbers of monocytes which by themselves were unable to support T-cell proliferation synergistically augmented antigen presentation by thyrocytes. These results suggest that cellular interactions among thyrocytes, monocytes and T cells may perpetuate immune or autoimmune responses in thyroid tissues from Graves' patients.
- Subjects
GRAVES' disease; ANTIGENS; EPITHELIAL cells; THYROID gland; MONOCYTES; T cells
- Publication
Clinical & Experimental Immunology, 1988, Vol 72, Issue 1, p84
- ISSN
0009-9104
- Publication type
Article