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- Title
Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study.
- Authors
Fiorelli, Alfonso; D'Andrilli, Antonio; Carlucci, Annalisa; Vicidomini, Giovanni; Argento, Giacomo; Trabalza Marinucci, Beatrice; Ardissone, Francesco; Rapanà, Roberta; Sobrero, Simona; Carbognani, Paolo; Ventura, Luigi; Bocchialini, Giovanni; Ragusa, Mark; Tassi, Valentina; Sollitto, Francesco; Loizzi, Domenico; Ardò, Nicoletta Pia; Anile, Marco; Puma, Francesco; Rendina, Erino Angelo
- Abstract
Purpose: Pulmonary hamartoma is the most common benign tumor of the lung. We analyzed a 20-year historical series of patients with pulmonary hamartoma undergoing surgical resection, aiming to evaluate the characteristics, the outcomes, and the association between hamartoma and lung cancer. Methods: It was a retrospective multicenter study including the data of all consecutive patients with pulmonary hamartoma undergoing surgical resection. The end-points were to evaluate: (i) the characteristics of hamartoma, (ii) outcomes, and (iii) whether hamartoma was a predictive factor for lung cancer development Results: Our study population included 540 patients. Upfront surgical or endoscopic resection was performed in 385 (71%) cases while in the remaining 155 (29%) cases, the lesions were resected 20 ± 3.5 months later due to increase in size. In most cases, lung sparing resection was carried out including enucleation (n = 259; 48%) and wedge resection (n = 230; 43%) while 5 (1%) patients underwent endoscopic resection. Only two patients (0, 2%) had major complications. One patient (0.23%) had recurrence after endoscopic resection, while no cases of malignant degeneration were seen (mean follow-up:103.3 ± 93 months). Seventy-six patients (14%) had associated lung cancer, synchronous in 9 (12%) and metachronous in 67 (88%). Only age > 70-year-old (p = 0.0059) and smokers > 20 cigarettes/day (p < 0.0001) were the significant risk factors for lung cancer. Conclusion: PH was a benign tumor, with no evidence of recurrence and/or of malignant degeneration after resection. The association between hamartoma and lung cancer was a spurious phenomenon due to common risk factors.
- Subjects
HAMARTOMA; LUNG cancer; ENDOSCOPIC surgery; BENIGN tumors; ENUCLEATION of the eye; SURGICAL excision; LUNG tumors
- Publication
Lung, 2021, Vol 199, Issue 4, p369
- ISSN
0341-2040
- Publication type
Article
- DOI
10.1007/s00408-021-00460-8