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- Title
Coinfection with Zika Virus (ZIKV) and Dengue Virus Results in Preferential ZIKV Transmission by Vector Bite to Vertebrate Host.
- Authors
Chaves, Barbara Aparecida; Orfano, Alessandra Silva; Nogueira, Paula Monalisa; Rodrigues, Nilton Barnabe; Campolina, Thais Bonifácio; Nacif-Pimenta, Rafael; Pires, Ana Clara Araújo Machado; Júnior, Ademir Bentes Vieira; Paz, Andréia da Costa; Vaz, Evelyn Beatriz da Costa; Campolina, Thais Bonifácio; Pires, Ana Clara Araújo Machado; Júnior, Ademir Bentes Vieira; Paz, Andréia da Costa; Guerra, Maria das Graças Vale Barbosa; Silva, Breno Melo; de Melo, Fabrício Freire; Norris, Douglas Eric; de Lacerda, Marcus Vinícius Guimarães; Pimenta, Paulo Filemon Paolucci
- Abstract
<bold>Background: </bold>Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses.<bold>Methods: </bold>A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice.<bold>Results: </bold>A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host.<bold>Conclusions: </bold>This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.
- Subjects
ZIKA virus infections; AEDES aegypti; DENGUE viruses; FLAVIVIRUSES; FLAVIVIRAL diseases
- Publication
Journal of Infectious Diseases, 2018, Vol 218, Issue 4, p563
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy196