We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Determination of Thiafentanil in Plasma Using LC–MS.
- Authors
Cox, Sherry; Bergman, Joan; Allender, Matthew C; Beckmen, Kimberlee; Lance, William
- Abstract
A new method of analysis has been developed and validated for the determination of thiafentanil in plasma. After protein precipitation, samples were separated on an XBridge BEH C18 column and quantified using mass spectrometry. The mobile phase was a mixture of water with 0.1% formic acid and acetonitrile with 0.1% formic acid (90:10). The standard curve ranged from 0.1 to 25 ng/mL. Intra- and Inter-assay variability for thiafentanil was less than 10%, and the average recovery was greater than 95%. The lower limit of quantification was 0.1 ng/mL. This is the first validated method for thiafentanil analysis in plasma.
- Subjects
FORMIC acid; ACETONITRILE
- Publication
Journal of Chromatographic Science, 2020, Vol 58, Issue 1, p1
- ISSN
0021-9665
- Publication type
Article
- DOI
10.1093/chromsci/bmz098