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- Title
Sympathetic cardiac function in early sepsis: Noninvasive evaluation with [<sup>123</sup>I]-meta-iodobenzylguanidine (<sup>123</sup>I-MIBG) in vivo SPECT imaging.
- Authors
Clerc, Romain; Doll, Sophia; Riou, Laurent M.; Perret, Pascale; Broisat, Alexis; Soubies, Audrey; Desruet, Marie-Dominique; Fagret, Daniel; Schwebel, Carole; Ghezzi, Catherine
- Abstract
<bold>Background: </bold>Sympathetic system abnormalities have been reported in sepsis-related cardiac dysfunction. The present study aimed at evaluating the potential of the norepinephrine radiolabeled analogue [123I]-meta-iodobenzylguanidine (123I-MIBG) for the noninvasive assessment of modifications in cardiac sympathetic activity occurring in lipopolysaccharide (LPS)-induced experimental acute sepsis by single-photon emission computed tomographic imaging (SPECT).<bold>Methods and Results: </bold>Sepsis was induced in male Wistar rats by intraperitoneal injection of 10 mg·kg-1 lipopolysaccharide (n = 16), whereas control animals (n = 7) were injected with vehicle (NaCl 0.9%). Echocardiography in LPS-injected animals (n = 8) demonstrated systolic and diastolic cardiac dysfunction. 123I-MIBG was injected 1 hour after LPS or vehicle administration (n = 8 and 7, respectively), and in vivo SPECT imaging was performed early and late (20 and 180 minutes) after tracer injection prior to animal euthanasia and ex vivo assessment of 123I-MIBG biodistribution. Global and 17-segment SPECT image analysis indicated that early 123I-MIBG activity was not affected by LPS treatment, whereas late cardiac tracer activity was significantly decreased in LPS-treated animals. Consequently, the cardiac washout of 123I-MIBG was significantly higher in LPS-treated (63.3% ± 4.0%) than that in control animals (56.7% ± 5.8%) (P < .05).<bold>Conclusion: </bold>Sepsis-induced modifications in cardiac sympathetic nervous system activity were evidenced by noninvasive in vivo 123I-MIBG SPECT imaging.
- Subjects
SINGLE-photon emission computed tomography; SEPSIS; RADIONUCLIDE imaging; HEART diseases; NORADRENALINE; SYMPATHETIC nervous system; DISEASE risk factors
- Publication
Journal of Nuclear Cardiology, 2018, Vol 25, Issue 2, p483
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-016-0619-8