We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach.
- Authors
Yoshii, M; Tanaka, H; Ohira, M; Muguruma, K; Iwauchi, T; Lee, T; Sakurai, K; Kubo, N; Yashiro, M; Sawada, T; Hirakawa, K
- Abstract
Background:It was recently reported that the transcription factor Forkhead box P3 (FoxP3) is expressed not only in regulatory T cells (Tregs) but also in cancer cells. The aim of this study was to clarify the clinical significance of FoxP3 expression in gastric carcinoma.Methods:We performed immunohistochemical staining of FoxP3 to examine the association of FoxP3 expression with clinicopathological features of 194 patients with gastric cancer who underwent surgical resection from 2000 to 2010. We also investigated the immunosuppressive function of FoxP3 using gastric cancer cell lines.Results:Immunohistochemical staining indicated FoxP3-positive cells within tumour tissue including both Tregs and tumour cells. Forkhead box P3-positive tumour cells were observed in 79.3% of signet ring cell carcinoma patients, and the expression of FoxP3 showed a significant correlation with lymph node metastasis. We showed that transforming growth factor-β augmented FoxP3 mRNA expression in cell lines derived from signet ring cell carcinoma. Indoleamine-2,3-dioxygenase and galectin-1, key effectors of Treg-mediated immunosuppression, were downregulated by FoxP3 knockdown.Conclusion:Our findings suggested that FoxP3 expression by tumour cells might have important roles in immune escape of gastric carcinoma, and be associated with the malignant potential of scirrhous gastric carcinoma.
- Subjects
FORKHEAD transcription factors; GASTROINTESTINAL cancer; IMMUNOMODULATORS; IMMUNOSUPPRESSIVE agents; LYMPH nodes; DIOXYGENASES; INDOLEAMINE 2,3-dioxygenase
- Publication
British Journal of Cancer, 2012, Vol 106, Issue 10, p1668
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/bjc.2012.141