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- Title
Preliminary report on the use of danazol in the treatment of endometrial adenomatous hyperplasia.
- Authors
Terakawa, Naoki; Inoue, Masaki; Shimizu, Ikuya; Ikegami, Hiromasa; Mizutani, Takahiro; Sakata, Masahiro; Tanizawa, Osamu; Matsumoto, Keishi; Terakawa, N; Inoue, M; Shimizu, I; Ikegami, H; Mizutani, T; Sakata, M; Tanizawa, O; Matsumoto, K
- Abstract
Since the authors recently reported that danazol inhibits the growth of human endometrial cancer cells in vitro, a clinical trial was initiated to examine whether danazol can regress adenomatous hyperplasia, a precursor of endometrial adenocarcinoma. Danazol was used for 3 months in the treatment of five patients with a history of hypermenorrhea and irregular uterine bleeding. Within a 9-month follow-up period, all patients were symptom-free, and none of the specimens obtained by endometrial biopsy showed the presence of adenomatous hyperplasia. These findings suggest that danazol has a potential application in the treatment of patients with endometrial adenomatous hyperplasia. A possible mechanism of action of the compound in adenomatous hyperplasia is also discussed.
- Subjects
PROTEIN analysis; STEROID drugs; ADENOMA; CELL receptors; COMPARATIVE studies; DANAZOL; ENDOMETRIUM; RESEARCH methodology; MEDICAL cooperation; RESEARCH; UTERINE diseases; UTERINE tumors; EVALUATION research
- Publication
Cancer (0008543X), 1988, Vol 62, Issue 12, p2618
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19881215)62:12<2618::AID-CNCR2820621228>3.0.CO;2-I