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- Title
Associations between α<sup>+</sup>-Thalassemia and Plasmodium falciparum Malarial Infection in Northeastern Tanzania.
- Authors
Enevold, Anders; Alifrangis, Michael; Sanchez, Juan J.; Carneiro, Ilona; Roper, Cally; Børsting, Claus; Lusingu, John; Vestergaard, Lasse S.; Lemnge, Martha M.; Morling, Niels; Riley, Eleanor; Drakeley, Chris J.
- Abstract
Background. The 2 most common hemoglobinopathies, sickle cell trait and α+-thalassemia, confer partial resistance to fatal forms of malaria, but the molecular basis for this protection is still not understood. Examination of the relationship between these traits and malaria transmission intensity may provide insights into the protection afforded. Methods. The distribution of the 2 traits was assessed among children resident in 13 villages in the Eastern Arc Mountains in Tanzania, where Plasmodium falciparum transmission intensity is closely correlated with altitude. Associations between the prevalence of the 2 traits and malariometric indices were investigated by logistic regression. Short tandem repeat (STR) microsatellite allele frequencies were used to assess population substructuring. Results. The frequency of α+-thalassemia ranged from 10%–25% in high-altitude villages (>1200 m) to 45%– 55% in low-altitude villages (<600 m). The carriage rate of α+-thalassemia decreased by ∼12% per 100-m increase in altitude (P<.001) and was ∼50% lower among those with patent parasitemia than among uninfected individuals (P = .014). The prevalence of the sickle cell trait was lower than that of α+-thalassemia (range, 0%–14%) and was significantly associated with village altitude only (P=.011). STR allele frequencies were similar in all villages. Conclusions. In this malaria-endemic region of Tanzania, α+-thalassemia is common and clearly associated with P. falciparum transmission intensity. There was no evidence of population substructuring, and the results are suggestive of selection of the α3.7 allele by malaria.
- Subjects
TANZANIA; THALASSEMIA; PLASMODIUM falciparum; MICROBIAL virulence -- Molecular aspects; INFECTIOUS disease transmission; EPIDEMIOLOGY; MOLECULAR biology; PUBLIC health
- Publication
Journal of Infectious Diseases, 2007, Vol 196, Issue 3, p451
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/519390