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- Title
Cyclosporin A treatment and airways inflammation in corticosteroid-dependent asthma.
- Authors
Redington, A. E.; Hardinge, F. M.; Madden, J.; Holgate, S. T.; Howarth, P. H.
- Abstract
Cyclosporin A is a potent immunosuppressive agent which inhibits activation of T cells and other inflammatory cells. It has been shown to be of clinical benefit in patients with corticosteroid-dependent asthma, but there are no data on its in vivo effects on airways inflammation. In this report, we describe the case of a 47-year-old man with chronic severe corticosteroid-dependent asthma who made a dramatic clinical response to therapy with cyclosporin A. Fibreoptic bronchoscopy with bronchoalveolar lavage and endobronchial biopsy were performed before and after a 12-month period of treatment with cyclosporin A and demonstrated a concomitant reduction in airway inflammatory indices.
- Subjects
CYCLOSPORINE; IMMUNOSUPPRESSIVE agents; DRUG therapy for asthma; T cells; CORTICOSTEROIDS
- Publication
Allergy, 1998, Vol 53, Issue 1, p94
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.1998.tb03780.x