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- Title
Multiple angiogenetic factors are upregulated in POEMS syndrome.
- Authors
Yamada, Yuta; Sawai, Setsu; Misawa, Sonoko; Kanai, Kazuaki; Shibuya, Kazumoto; Mori, Masahiro; Moriya, Junji; Sogawa, Kazuyuki; Yamamoto, Haruna; Beppu, Minako; Taniguchi, Junko; Nakaseko, Chiaki; Nomura, Fumio; Kuwabara, Satoshi
- Abstract
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a multisystem disorder associated with plasma cell dyscrasia. Elevated serum levels of vascular endothelial growth factor (VEGF), which strongly promotes neovascularization and vasopermeability, are considered to be responsible for the characteristic symptoms such as angiomata, pleural effusion/ascites, edema, and organomegaly in the disorder. To study whether other angiogenetic factors are upregulated in POEMS syndrome, we measured serum levels of basic fibroblast growth factor and hepatocyte growth factor (HGF), as well as VEGF, in 17 patients with POEMS syndrome. All these factors were significantly upregulated in the POEMS syndrome patients. After the treatment with anti-VEGF antibody, the levels of HGF did not change, suggesting that elevation of HGF levels is not secondary to VEGF overproduction. These results suggest that different angiogenetic factors might contribute to the pathogenesis of POEMS syndrome, and this fact might contribute to the insufficient clinical effects obtained by suppression of VEGF alone.
- Subjects
HEPATOCYTE growth factor; FIBROBLAST growth factors; VASCULAR endothelial growth factors; POEMS syndrome; NEOVASCULARIZATION; CYTOKINES
- Publication
Annals of Hematology, 2013, Vol 92, Issue 2, p245
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-012-1583-2