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- Title
Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes.
- Authors
Zareparsi, Sepideh; Kaye, Jeffrey; Camicioli, Richard; Grimslid, Holly; Oken, Barry; Litt, Michael; Nutt, John; Bird, Thomas; Schellenberg, Gerard; Payami, Haydeh
- Abstract
Parkinson's disease (PD) patients often develop dementia, and Alzheimer's disease (AD) patients frequently develop parkinsonian signs. The apolipoprotein E σ4 allele is associated with increased risk and earlier onset of AD. We studied 137 unrelated white PD patients. Those with σ4 had the earliest onset (52.7 · 9.8 years), σ3/σ3 patients had an intermediate onset (56.1 · 11.1 years), and those with σ2 had the latest onset (59.1 · 13.4 years). The age at onset distribution for σ4/σ - was significantly earlier than for σ3/σ3 and σ2/σ3. These preliminary results suggest that apolipoprotein E genotypes modulate the age at onset of PD.
- Publication
Annals of Neurology, 1997, Vol 42, Issue 4, p655
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410420417