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- Title
Mechanisms of excitability in the thalamocortical circuit.
- Authors
Huguenard, John
- Abstract
The thalamocortical system consists of widespread excitatory connections between cortical and subcortical structures. Synaptic excitation and inhibition play subcircuit-specific roles in its function. Generalized absence seizures result from either increased/decreased inhibition or excitation, depending on the subcircuit, yet a common feature of absence seizures in thalamus is net increased inhibition, with therapeutic implications. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at ).
- Subjects
EPILEPSY; BRAIN diseases; DEVELOPMENTAL disabilities; THALAMUS; NEURAL transmission
- Publication
Epilepsia (Series 4), 2010, Vol 51, p25
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/j.1528-1167.2010.02811.x