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- Title
Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2).
- Authors
Yong Su; Chuan-wei Mo; Wan-qin Cheng; Lei Wang; Qian Xu; Zu-chun Wu; Zhe-li Wu; Li-zhi Liu; Xin-lin Chen; Su, Yong; Mo, Chuan-Wei; Cheng, Wan-Qin; Wang, Lei; Xu, Qian; Wu, Zu-Chun; Wu, Zhe-Li; Liu, Li-Zhi; Chen, Xin-Lin
- Abstract
<bold>Background: </bold>The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients.<bold>Methods: </bold>The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC.<bold>Results: </bold>A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were >0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H&N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from -0.82 to -0.22.<bold>Conclusions: </bold>The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients.
- Subjects
QUALITY of life; NASOPHARYNX cancer patients; RADIOTHERAPY; CLASSICAL test theory; CRONBACH'S alpha; STANDARD deviations; CONFIDENCE intervals; MENTAL health; NASOPHARYNX tumors; PSYCHOMETRICS; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; PATIENT satisfaction; PATIENT psychology; RESEARCH; RESEARCH evaluation; ASIANS; SOCIOECONOMIC factors; EVALUATION research; HUMAN services programs; PSYCHOLOGY; TUMOR treatment; EQUIPMENT &; supplies
- Publication
Health & Quality of Life Outcomes, 2016, Vol 14, p1
- ISSN
1477-7525
- Publication type
journal article
- DOI
10.1186/s12955-016-0480-0