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- Title
Effect of Levetiracetam on Oxidant–Antioxidant Activity during Long-Term Temporal Lobe Epilepsy in Rats.
- Authors
Ignacio-Mejía, Iván; Contreras-García, Itzel Jatziri; Pichardo-Macías, Luz Adriana; García-Cruz, Mercedes Edna; Ramírez Mendiola, Blanca Alcira; Bandala, Cindy; Medina-Campos, Omar Noel; Pedraza-Chaverri, José; Cárdenas-Rodríguez, Noemí; Mendoza-Torreblanca, Julieta Griselda
- Abstract
Epilepsy is a disorder characterized by a predisposition to generate seizures. Levetiracetam (LEV) is an antiseizure drug that has demonstrated oxidant–antioxidant effects during the early stages of epilepsy in several animal models. However, the effect of LEV on oxidant–antioxidant activity during long-term epilepsy has not been studied. Therefore, the objective of the present study was to determine the effects of LEV on the concentrations of five antioxidant enzymes and on the levels of four oxidant stress markers in the hippocampus of rats with temporal lobe epilepsy at 5.7 months after status epilepticus (SE). The results revealed that superoxide dismutase (SOD) activity was significantly greater in the epileptic group (EPI) than in the control (CTRL), CTRL + LEV and EPI + LEV groups. No significant differences were found among the groups' oxidant markers. However, the ratios of SOD/hydrogen peroxide (H2O2), SOD/glutathione peroxidase (GPx) and SOD/GPx + catalase (CAT) were greater in the EPI group than in the CTRL and EPI + LEV groups. Additionally, there was a positive correlation between SOD activity and GPx activity in the EPI + LEV group. LEV-mediated modulation of the antioxidant system appears to be time dependent; at 5.7 months after SE, the role of LEV may be as a stabilizer of the redox state.
- Subjects
TEMPORAL lobe epilepsy; EPILEPSY in animals; GLUTATHIONE peroxidase; TIME pressure; SUPEROXIDE dismutase
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 17, p9313
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25179313