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- Title
Antihypertensive Effects of Lindera erythrocarpa Makino via NO/cGMP Pathway and Ca 2+ and K + Channels.
- Authors
Shin, Sujin; Park, Junkyu; Choi, Ho-Young; Bu, Youngmin; Lee, Kyungjin
- Abstract
Studies have demonstrated the therapeutic effects of Lindera plants. This study was undertaken to reveal the antihypertensive properties of Lindera erythrocarpa leaf ethanolic extract (LEL). Aorta segments of Sprague–Dawley rats were used to study the vasodilatory effect of LEL, and the mechanisms involved were evaluated by treating specific inhibitors or activators that affect the contractility of blood vessels. Our results revealed that LEL promotes a vasorelaxant effect through the nitric oxide/cyclic guanosine 3′,5′-monophosphate pathway, blocking the Ca2+ channels, opening the K+ channels, and inhibiting the vasoconstrictive action of angiotensin II. In addition, the effects of LEL on blood pressure were investigated in spontaneously hypertensive rats by the tail-cuff method. LEL (300 or 1000 mg/kg) was orally administered to the rats, and 1000 mg/kg of LEL significantly lowered the blood pressure. Systolic blood pressure decreased by −20.06 ± 4.87%, and diastolic blood pressure also lowered by −30.58 ± 5.92% at 4 h in the 1000 mg/kg LEL group. Overall, our results suggest that LEL may be useful to treat hypertensive diseases, considering its vasorelaxing and hypotensive effects.
- Subjects
PHYTOTHERAPY; NITRIC oxide; HYPERTENSION; CALCIUM channels; POTASSIUM; VASOCONSTRICTION; ANTIHYPERTENSIVE agents; CELLULAR signal transduction; DESCRIPTIVE statistics; PLANT extracts; NUCLEOTIDES; RATS; MEDICINAL plants; ANIMAL experimentation; ANGIOTENSIN II; DIASTOLIC blood pressure; LEAVES; BLOOD pressure; SYSTOLIC blood pressure; PHARMACODYNAMICS
- Publication
Nutrients, 2024, Vol 16, Issue 17, p3003
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16173003