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- Title
Short-chain fatty acids play a positive role in colorectal cancer.
- Authors
Liu, Gang; Tang, Jingtong; Zhou, Jianping; Dong, Ming
- Abstract
Short-chain fatty acids (SCFAs) are produced by bacterial fermentation in the colon and are thought to be protective against gastrointestinal disease. SCFAs such as acetate, propionate and butyrate are important metabolites in the maintenance of intestinal homeostasis and have been shown to be beneficial in colorectal cancer (CRC). SCFAs are responsible for maintaining a normal intestinal barrier and exhibit numerous immunomodulatory functions. In this review article, we will discuss the metabolism and mechanism of action of SCFAs and their effects on the CRC, with particular emphasis on dietary fiber treatment and the clinical research progress.
- Subjects
SHORT-chain fatty acids; COLORECTAL cancer; GASTROINTESTINAL diseases; DIETARY fiber; MEDICAL research
- Publication
Discover Oncology, 2024, Vol 15, Issue 1, p1
- ISSN
2730-6011
- Publication type
Article
- DOI
10.1007/s12672-024-01313-5