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- Title
Indicators of cure for women living after uterine and ovarian cancers: a population-based study.
- Authors
Giudici, Fabiola; Paoli, Angela De; Toffolutti, Federica; Guzzinati, Stefano; Francisci, Silvia; Bucchi, Lauro; Gatta, Gemma; Demuru, Elena; Mallone, Sandra; Cin, Antonella Dal; Caldarella, Adele; Cuccaro, Francesco; Migliore, Enrica; Gambino, Maria Letizia; Ravaioli, Alessandra; Puppo, Antonella; Ferrante, Margherita; Carrozzi, Giuliano; Stracci, Fabrizio; Musolino, Antonino
- Abstract
This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate net survival, cure fraction, time to cure (when 5-year conditional net survival becomes > 95%), cure prevalence (women who will not die of cancer), and already cured (living longer than time to cure). In 2018, 0.4% (121 704) of Italian women were alive after diagnosis of corpus uteri cancer, 0.2% (52 551) after cervical cancer, and 0.2% (52 153) after ovarian cancer. More than 90% of patients with uterine cancers and 83% with ovarian cancer will not die from their neoplasm (cure prevalence). Women with gynecological cancers have a residual excess risk of death <5% at 5 years after diagnosis. The cure fraction was 69% for corpus uteri, 32% for ovarian, and 58% for cervical cancer patients. Time to cure was ≤10 years for women with gynecological cancers aged <55 years; 74% of patients with cervical cancer, 63% with corpus uteri cancer, and 55% with ovarian cancer were already cured. These results can contribute to improving follow-up programs for women with gynecological cancers and supporting efforts against discrimination of already cured ones. This article is part of a Special Collection on Gynecological Cancers.
- Subjects
ITALY; MORTALITY risk factors; UTERINE tumors; CLINICAL medicine; RISK assessment; RESEARCH funding; OVARIAN tumors; CANCER patient medical care; KEY performance indicators (Management); PSYCHOLOGY of women; TREATMENT effectiveness; AGE distribution; TREATMENT duration; DISEASE prevalence; CANCER patient psychology; SURVIVAL analysis (Biometry); DISEASE incidence; EVALUATION
- Publication
American Journal of Epidemiology, 2024, Vol 193, Issue 9, p1224
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwae044