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- Title
Cardiovascular Risk in Patients with Inflammatory Bowel Diseases—The Role of Endothelial Dysfunction.
- Authors
Livzan, Maria A.; Bikbavova, Galiya R.; Lisyutenko, Natalya S.; Romanyuk, Alisa E.; Drapkina, Oxana M.
- Abstract
Inflammatory bowel disease (IBD) is associated with an increased risk of cardiovascular disease (CVD). Cardiovascular pathology in people with IBD has not been well studied to date, and a direct link between cardiovascular events and IBD has not been established. The mechanisms underlying this association include the parallel and dynamic interaction of inflammation, modulation of the composition of the gut microbiota, endothelial dysfunction, thrombogenicity, and increased endothelial and epithelial permeability. Endothelial dysfunction is a common aspect of the pathogenesis of IBD and atherosclerotic CVD and can be considered one of the most important factors leading to the development and progression of cardiovascular pathology in patients with IBD. The purpose of this literature review is to describe the mechanisms underlying the development of endothelial dysfunction and disorders of the structure and function of the gut–vascular barrier in the pathogenesis of the cardiovascular manifestation of IBD.
- Subjects
CROHN'S disease; INFLAMMATORY bowel diseases; CARDIOLOGICAL manifestations of general diseases; LITERATURE reviews; ULCERATIVE colitis; ENDOTHELIUM diseases
- Publication
Diagnostics (2075-4418), 2024, Vol 14, Issue 16, p1722
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics14161722