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- Title
Fas Stimulation Results in Selective Islet Infiltrate Apoptosis in Situ and Reversal of Diabetes.
- Authors
DHARNIDHARKA, VIKAS R.; PATTEN, YANCY VAN; BAHJAT, F. RENA; CLARE-SALZLER, MICHAEL
- Abstract
A bstract: Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.
- Publication
Annals of the New York Academy of Sciences, 2002, Vol 958, Issue 1, p160
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2002.tb02960.x