We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Structural Organization and Chromosomal Localization of Three Human Galanin Receptor Genes.
- Authors
IISMAA, TIINA P.; FATHI, ZAHRA; HORT, YVONNE J.; IBEN, LAWRENCE G.; DUTTON, JULIE L.; BAKER, ELIZABETH; SUTHERLAND, GRANT R.; SHINE, JOHN
- Abstract
A bstract: Human galanin receptor subtypes GALR1, GALR2, and GALR3 are encoded by separate genes that are located on human chromosomes 18q23, 17q25.3, and 22q13.1, respectively. The exon:intron organization of the gene encoding GALR2 ( GALNR2) and GALR3 ( GALNR3) is conserved, with exon 1 encoding the NH2-terminus to the end of transmembrane domain 3 and exon 2 encoding the remainder of the receptor, from the second intracellular loop to the COOH-terminus. This conservation of structural organization is indicative of a common evolutionary origin for GALNR2 and GALNR3. The exon:intron organization of the gene encoding GALR1 ( GALNR1) is different from that of GALNR2 and GALNR3, with exon 1 encoding the NH2-terminus to the end of transmembrane domain 5, exon 2 encoding the third intracellular loop, and exon 3 encoding the remainder of the receptor, from transmembrane domain 6 to the COOH-terminus. The structural organization of GALNR1 suggests convergent evolution for this gene and represents a structural organization that is unique among genes encoding G-protein-coupled receptors.
- Publication
Annals of the New York Academy of Sciences, 1998, Vol 863, Issue 1, p56
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1998.tb10683.x