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- Title
Changes in triglyceride, HDL-C, and non-HDL-C levels in patients with acute coronary syndrome.
- Authors
Koncsos, Péter; Fülöp, Péter; Juhász, Imre; Bíró, Klára; Márk, László; Simonyi, Gábor; Paragh, György
- Abstract
Background: Changes in high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels have been linked to residual cardiovascular risk, whereas non-HDL-C levels have been shown to be more predictive of cardiovascular risk than are low-density lipoprotein cholesterol (LDL-C) levels. We aimed to investigate the impact of HDL-C, TG, and non-HDL-C levels on acute coronary syndrome (ACS) risk with on-target LDL-C levels. Methods: In all, 424 Caucasian patients aged over 50 years who had LDL-C levels below 3.4 mmol/l with a first or subsequent ACS event were enrolled in a multicenter, retrospective study. Lipid samples were collected within 4 days after the cardiovascular event. The subjects of the age-matched, gender-balanced control group ( n = 443) had LDL-C levels below 3.4 mmol/l and were free of cardiovascular diseases. Results: Patients with ACS had significantly higher TG and lower HDL-C levels compared with the control patients; however, we did not find any significant difference regarding non-HDL-C levels between the two groups. In regression analysis, the risk of coronary heart disease increased significantly with 1 standard deviation (SD) increase in TG and 1 SD decrease in HDL-C levels. Conclusion: High TG and low HDL-C levels may contribute to residual cardiovascular risk in patients with well-controlled LDL-C levels; however, non-HDL-C levels at admission did not seem to be predictive for patients with ACS. Detection and treatment of secondary lipid targets such as high TG and low HDL-C levels may be important for the prevention of cardiovascular diseases.
- Subjects
TRIGLYCERIDES; ACUTE coronary syndrome; HIGH density lipoproteins; LOW density lipoproteins; CARDIOVASCULAR disease prevention
- Publication
Wiener Klinische Wochenschrift, 2016, Vol 128, Issue 23/24, p858
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-016-1035-4