We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Endometriosis and regional lymph node involvement in a rat model.
- Authors
Gong, Yao; Hong, Ling; Zheng, Chen-Chen; Tong, Xiao-Wen; Tempfer, Clemens B.
- Abstract
OBJECTIVE(S): To establish an experimental bowel endometriosis model in the rat and to investigate regional lymph node involvement. STUDY DESIGN: Twenty Sprague-Dawley rats were subjected to autologous transplantation of endometrial tissue to the ileocecum by laparotomy. After two months, endometriotic lesions and mesenteric lymph nodes were harvested by repeat laparotomy subjected to histologic assessment regarding the histologically verified presence of endometriosis in the ileocecum and in mesenteric lymph nodes. RESULT(S): A total of 20 rats were subjected to autologous transplantation of endometrial tissue to the ileocecum. Ileocecal endometriosis was successfully induced in 19/20 (95%) rats. In 18/20 animals, the mesenteric lymph node was identified and resected. Regional lymph node involvement by endometriosis was identified in 0/18 mesenteric lymph nodes. CONCLUSION(S): Endometriosis can be successfully induced in a rat model by autologous transplantation of endometrial tissue. In this experimental rodent endometriosis model, regional mesenteric lymph node involvement by endometriosis was not identified.
- Subjects
ENDOMETRIOSIS; LYMPH nodes; ENDOMETRIUM; TRANSPLANTATION of organs, tissues, etc.; ILEUM
- Publication
Wiener Klinische Wochenschrift, 2011, Vol 123, Issue 13/14, p432
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-011-0003-2