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- Title
The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases.
- Authors
Fanni, Daniela; Gerosa, C.; Nurchi, V. M.; Manchia, M.; Saba, L.; Coghe, F.; Crisponi, G.; Gibo, Y.; Van Eyken, P.; Fanos, V.; Faa, G.
- Abstract
Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood.
- Subjects
BONE growth; MAGNESIUM; PERINATAL period; FETAL diseases; SYMPTOMS; TRACE metals; FETAL presentation
- Publication
Biological Trace Element Research, 2021, Vol 199, Issue 10, p3647
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-020-02513-0