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- Title
An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3.
- Authors
Yang, Jing-Ming; Liu, Ya-Yue; Yang, Wen-Cong; Ma, Xiao-Xiang; Nie, Ying-Ying; Glukhov, Evgenia; Gerwick, Lena; Gerwick, William H.; Lei, Xiao-Ling; Zhang, Yi
- Abstract
A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven known compounds including isoflavones 2–6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate in vitro anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound 2 (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds 2, 5 (biochanin A), 6 (psoralenol), and 7 exhibited potent larvicidal activity against brine shrimp. Compounds 3 (daidzein), 4 (4ʹ-hydroxy-6,7-dimethoxyisoflavone), and 5–7 showed broad-spectrum anti-microbial activity, and compound 7 also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. An anti-inflammatory isoflavone from soybean fermented by a marine fungus Aspergillus terreus C23-3
- Subjects
MARINE fungi; ASPERGILLUS terreus; SOYBEAN; SOYBEAN varieties; ARTEMIA; ACETYLCHOLINESTERASE
- Publication
Bioscience, Biotechnology & Biochemistry, 2020, Vol 84, Issue 8, p1546
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2020.1764838