We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Tyrosinase inhibitory flavonoid from Juniperus communis fruits.
- Authors
Jegal, Jonghwan; Park, Sang-A; Chung, Kiwung; Chung, Hae Young; Lee, Jaewon; Jeong, Eun Ju; Kim, Ki Hyun; Yang, Min Hye
- Abstract
The fruits ofJuniperus communishave been traditionally used in the treatment of skin diseases. In our preliminary experiment, the MeOH extract ofJ. communiseffectively suppressed mushroom tyrosinase activity. Three monoflavonoids and five biflavonoids were isolated fromJ. communisby bioassay-guided isolation and their inhibitory effect against tyrosinase was evaluated. According to the results of all isolates, hypolaetin 7-O-β-xylopyranoside isolated fromJ. communisexhibited most potent effect of decreasing mushroom tyrosinase activity with an IC50value of 45.15 μM. Further study provided direct experimental evidence for hypolaetin 7-O-β-D-xylopyranoside-attenuated tyrosinase activity in α-MSH-stimulated B16F10 murine melanoma cell. Hypolaetin 7-O-β-D-xylopyranoside from the EtOAc fraction ofJ. communiswas also effective at suppressing α-MSH-induced melanin synthesis. This is the first report of the enzyme tyrosinase inhibition byJ. communisand its constituent. Therapeutic attempts withJ. communisand its active component, hypolaetin 7-O-β-D-xylopyranoside, might be useful in treating melanin pigmentary disorders. According to bioactivity-guided isolation, hypolaetin 7-O-β-D-xylopyranoside fromJ. communiswas effective at suppressing tyrosinase activity and melanin synthesis.
- Subjects
JUNIPERUS communis; FLAVONOIDS; SKIN disease treatment; THERAPEUTICS
- Publication
Bioscience, Biotechnology & Biochemistry, 2016, Vol 80, Issue 12, p2311
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2016.1217146