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- Title
Age-Dependent Sex Differences in the Prevalence of Selective Serotonin Reuptake Inhibitor Treatment: A Retrospective Cohort Analysis.
- Authors
Sanchez-Ruiz, Jorge A.; Leibman, Nicole I.; Larson, Nicholas B.; Jenkins, Gregory D.; Ahmed, Ahmed T.; Nunez, Nicolas A.; Biernacka, Joanna M.; Winham, Stacey J.; Weinshilboum, Richard M.; Wang, Liewei; Frye, Mark A.; Ozerdem, Aysegul
- Abstract
Background: Antidepressants are among the most prescribed medications in the United States. The aim of this study was to explore the prevalence of antidepressant prescriptions and investigate sex differences and age-sex interactions in adults enrolled in the Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment (RIGHT) study. Materials and Methods: We conducted a retrospective analysis of the RIGHT study. Using electronic prescriptions, we assessed 12-month prevalence of antidepressant treatment. Sex differences and age-sex interactions were evaluated using multivariable logistic regression and flexible recursive smoothing splines. Results: The sample consisted of 11,087 participants (60% women). Antidepressant prescription prevalence was 22.24% (27.96% women, 13.58% men). After adjusting for age and enrollment year, women had significantly greater odds of antidepressant prescription (odds ratio = 2.29; 95% confidence interval = 2.07, 2.54). Furthermore, selective serotonin reuptake inhibitors (SSRIs) had a significant age-sex interaction. While SSRI prescriptions in men showed a sustained decrease with age, there was no such decline for women until after reaching ∼50 years of age. There are important limitations to consider in this study. Electronic prescription data were cross-sectional; information on treatment duration or adherence was not collected; this cohort is not nationally representative; and enrollment occurred over a broad period, introducing confounding by changes in temporal prescribing practices. Conclusions: Underscored by the significant interaction between age and sex on odds of SSRI prescription, our results warrant age to be incorporated as a mediator when investigating sex differences in mental illness, especially mood disorders and their treatment.
- Subjects
ANTIDEPRESSANTS; CONFIDENCE intervals; SEROTONIN uptake inhibitors; AGE distribution; MULTIPLE regression analysis; RETROSPECTIVE studies; MENTAL health; SEX distribution; DRUG prescribing; RESEARCH funding; PHYSICIAN practice patterns; ODDS ratio; HEALTH equity; MEDICAL needs assessment; SECONDARY analysis
- Publication
Journal of Women's Health (15409996), 2023, Vol 32, Issue 11, p1229
- ISSN
1540-9996
- Publication type
Article
- DOI
10.1089/jwh.2022.0484