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- Title
Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation.
- Authors
Li, Qiyao; Li, Ying; Min, Tianliang; Gong, Junyi; Du, Lili; Phillips, David Lee; Liu, Junkai; Lam, Jacky W. Y.; Sung, Herman H. Y.; Williams, Ian D.; Kwok, Ryan T. K.; Ho, Chun Loong; Li, Kai; Wang, Jianguo; Tang, Ben Zhong
- Abstract
Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small ΔEST, 4TPA‐BQ shows a satisfactorily high 1O2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.
- Subjects
PHOTODYNAMIC therapy; CANCER cells; PHOTOSENSITIZERS; ORGANIC synthesis; REACTIVE oxygen species
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 24, p9557
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201909706