We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Supported Catalytically Active Supramolecular Hydrogels for Continuous Flow Chemistry.
- Authors
Rodon Fores, Jennifer; Criado‐Gonzalez, Miryam; Chaumont, Alain; Carvalho, Alain; Blanck, Christian; Schmutz, Marc; Serra, Christophe A.; Boulmedais, F.; Schaaf, Pierre; Jierry, Loïc
- Abstract
Inspired by biology, one current goal in supramolecular chemistry is to control the emergence of new functionalities arising from the self‐assembly of molecules. In particular, some peptides can self‐assemble and generate exceptionally catalytically active fibrous networks able to underpin hydrogels. Unfortunately, the mechanical fragility of these materials is incompatible with process developments, relaying this exciting field to academic curiosity. Here, we show that this drawback can be circumvented by enzyme‐assisted self‐assembly of peptides initiated at the walls of a supporting porous material. We applied this strategy to grow an esterase‐like catalytically active supramolecular hydrogel (CASH) in an open‐cell polymer foam, filling the whole interior space. Our supported CASH material is highly efficient towards inactivated esters and enables the kinetic resolution of racemates. This hybrid material is robust enough to be used in continuous flow reactors, and is reusable and stable over months.
- Subjects
FLOW chemistry; CONTINUOUS flow reactors; POROUS materials; HYDROGELS; SUPRAMOLECULAR chemistry; KINETIC resolution
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 52, p18993
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201909424