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- Title
Total Synthesis of (−)‐Perezoperezone through an Intermolecular [5+2] Homodimerization of Hydroxy p‐Quinone.
- Authors
Long, Yang; Ding, Yiming; Wu, Hai; Qu, Chunlei; Liang, Hong; Zhang, Min; Zhao, Xiaoli; Long, Xianwen; Wang, Shu; Puno, Pema‐Tenzin; Deng, Jun
- Abstract
The first copper‐catalyzed intermolecular [5+2] homodimerization of hydroxy p‐quinone is presented, furnishing bicyclo[3.2.1]octadienone core structures in typically good yields and excellent diastereoselectivities. Applying this synthetic approach enables a concise nine‐step total synthesis of (−)‐perezoperezone from commercially available 3,5‐dimethoxytoluene.
- Subjects
QUINONE; BUILDINGS
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 49, p17716
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201911978