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- Title
Rhodium‐Catalyzed Parallel Kinetic Resolution of Racemic Internal Allenes Towards Enantiopure Allylic 1,3‐Diketones.
- Authors
Hilpert, Lukas J.; Breit, Bernhard
- Abstract
A rare case of a parallel kinetic resolution of racemic 1,3‐disubstituted allenes by means of a rhodium‐catalyzed addition to 1,3‐diketones furnishing enantiopure allylic 1,3‐diketones is described. Mechanistic experiments demonstrate that the different allene enantiomers react in parallel to either the diastereomeric E‐ or Z‐allylic 1,3‐diketones with the same absolute configuration of the newly formed stereogenic center. A broad substrate scope demonstrates the synthetic utility of this new method.
- Subjects
ALLENE; KINETIC resolution; ENANTIOMERS
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 29, p10044
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201903365