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- Title
Ring Opening Metathesis Polymerization of Bicyclic α,β‐Unsaturated Anhydrides for Ready‐to‐be‐grafted Polymers Having Tailored pH‐Responsive Degradability.
- Authors
Kim, Heejin; Kim, Sungwhan; Kang, Sunyoung; Song, Youngjun; Shin, Suyong; Lee, Seonju; Kang, Minji; Nam, So Hee; Lee, Yan
- Abstract
Abstract: Polymers having α,β‐unsaturated anhydrides as repeating units were synthesized by ring opening metathesis polymerization (ROMP). The anhydride moieties were ready‐to‐be‐grafted with amines to form acid‐labile cis‐α,β‐unsaturated acid amide linkages. The pH‐responsive reversible de‐grafting can be controlled by changing the intramolecular accessibility between acid and amide groups. The alendronate‐grafted ROMP polymers showed distinct pH‐dependent cytotoxicity according to the anhydride structures.
- Subjects
POLYMERS; METATHESIS reactions; AMIDES; HYDROGEN-ion concentration; ANHYDRIDES
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 38, p12648
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201806763