We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis.
- Authors
Miao, Tingting; Tian, Zi ‐ You; He, Yan ‐ Mei; Chen, Fei; Chen, Ya; Yu, Zhi ‐ Xiang; Fan, Qing ‐ Hua
- Abstract
The first asymmetric hydrogenation of in situ generated isochromenylium derivatives is enabled by tandem catalysis with a binary system consisting of Cu(OTf)2 and a chiral cationic ruthenium-diamine complex. A range of chiral 1 H-isochromenes were obtained in high yields with good to excellent enantioselectivity. These chiral 1 H-isochromenes could be easily transformed into isochromanes, which represent an important structural motif in natural products and biologically active compounds. The chiral induction was rationalized by density functional theory calculations.
- Subjects
HYDROGENATION; ADDITION reactions; SURFACE chemistry; CATALYSIS; PHYSICAL &; theoretical chemistry
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 15, p4199
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201611291