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- Title
Molecularly Regulated Reversible DNA Polymerization.
- Authors
Chen, Niancao; Shi, Xuechen; Wang, Yong
- Abstract
Natural polymers are synthesized and decomposed under physiological conditions. However, it is challenging to develop synthetic polymers whose formation and reversibility can be both controlled under physiological conditions. Here we show that both linear and branched DNA polymers can be synthesized via molecular hybridization in aqueous solutions, on the particle surface, and in the extracellular matrix (ECM) without the involvement of any harsh conditions. More importantly, these polymers can be effectively reversed to dissociate under the control of molecular triggers. Since nucleic acids can be conjugated with various molecules or materials, we anticipate that molecularly regulated reversible DNA polymerization holds potential for broad biological and biomedical applications.
- Subjects
DNA polymerases; BIOPOLYMERS; CHEMICAL synthesis; NUCLEIC acid hybridization; AQUEOUS solutions; EXTRACELLULAR matrix
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 23, p6769
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201601008