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- Title
Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins.
- Authors
Zhu, Xi; Wu, Jun; Shan, Wei; Tao, Wei; Zhao, Lili; Lim, Jong ‐ Min; D'Ortenzio, Mathew; Karnik, Rohit; Huang, Yuan; Shi, Jinjun; Farokhzad, Omid C.
- Abstract
Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide-ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ligands on the particle surface and simultaneously carrying therapeutic proteins inside by a self-assembly procedure. The loaded therapeutic proteins (e.g., insulin) within the NPs exhibited sustained and tunable release, while the surface-coated protein ligands (e.g., transferrin) were demonstrated to alter the NP cellular behaviors. In vivo results revealed that the transferrin-coated NPs can effectively be transported across the intestinal epithelium for oral insulin delivery, leading to a notable hypoglycemic response.
- Subjects
NANOMEDICAL research; DRUG delivery systems; THERAPEUTIC use of proteins; POLYMER research; TRANSFERRIN
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 10, p3370
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201509183