We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging.
- Authors
Hyun, Hoon; Owens, Eric A.; Wada, Hideyuki; Levitz, Andrew; Park, GwangLi; Park, Min Ho; Frangioni, John V.; Henary, Maged; Choi, Hak Soo
- Abstract
A novel class of near-infrared fluorescent contrast agents was developed. These agents target cartilage with high specificity and this property is inherent to the chemical structure of the fluorophore. After a single low-dose intravenous injection and a clearance time of approximately 4 h, these agents bind to all three major types of cartilage (hyaline, elastic, and fibrocartilage) and perform equally well across species. Analysis of the chemical structure similarities revealed a potential pharmacophore for cartilage targeting. Our results lay the foundation for future improvements in tissue engineering, joint surgery, and cartilage-specific drug development.
- Subjects
FLUOROPHORES; CONTRAST media; CHEMICAL structure; CARTILAGE; DIAGNOSTIC imaging research
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 30, p8772
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201502287