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- Title
Mechanochemical Rhodium(III)-Catalyzed CH Bond Functionalization of Acetanilides under Solventless Conditions in a Ball Mill.
- Authors
Hermann, Gary N.; Becker, Peter; Bolm, Carsten
- Abstract
In a proof-of-principle study, a planetary ball mill was applied to rhodium(III)-catalyzed CH bond functionalization. Under solventless conditions and in the presence of a minute amount of Cu(OAc)2, the mechanochemical activation led to the formation of an active rhodium species, thus enabling an oxidative Heck-type cross-coupling reaction with dioxygen as the terminal oxidant. The absence of an organic solvent, the avoidance of a high reaction temperature, the possibility of minimizing the amount of the metallic mediator, and the simplicity of the protocol result in a powerful and environmentally benign alternative to the common solution-based standard protocol.
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 25, p7522
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201502536