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- Title
Nanoelectrode for Amperometric Monitoring of Individual Vesicular Exocytosis Inside Single Synapses.
- Authors
Yu-Tao Li; Shu-Hui Zhang; Li Wang; Rong-Rong Xiao; Wei Liu; Xin-Wei Zhang; Zhuan Zhou; Amatore, Christian; Wei-Hua Huang
- Abstract
Chemical neurotransmission occurs at chemical synapses and endocrine glands, but up to now there was no means for direct monitoring of neurotransmitter exocytosis fluxes and their precise kinetics from inside an individual synapse. The fabrication of a novel finite conical nanoelectrode is reported perfectly suited in size and electrochemical properties for probing amperometrically inside what appears to be single synapses and monitoring individual vesicular exocytotic events in real time. This allowed obtaining direct and important physiological evidences which may yield important and new insights into the nature of synaptic communications.
- Subjects
NANOSTRUCTURED materials synthesis; EXOCYTOSIS; NANOFABRICATION; NEUROTRANSMITTERS; SYNAPSES; CARBON fibers; MICROELECTRODES
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 46, p12664
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201404744