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- Title
Histologic evaluation of Ki-67 and cleaved caspase-3 expression in feline mammary carcinoma.
- Authors
Silva, Millena N.; Leite, Juliana S.; Mello, Marcela F. V.; Silva, Kassia V. G. C.; Corgozinho, Katia B.; de Souza, Heloisa J. M.; Cunha, Simone C. S.; Ferreira, Ana M. R.
- Abstract
Objectives The purpose of this study was to evaluate histopathologic aspects of, and the expression of Ki-67 and cleaved caspase-3 in, feline mammary carcinoma (FMC). Methods Feline mammary tumors were surgically obtained by mastectomy from 30 female cats and were fixed with formalin and embedded in paraffin wax. Four-micron sections were stained with hematoxylin and eosin for histopathologic diagnosis. Ki-67 and cleaved caspase-3 were analyzed by immunohistochemistry. Results Samples were histologically confirmed as FMC. Positive immunostaining was observed in all cancer samples for both nuclear Ki-67 and cleaved caspase-3, with a mean positive staining percentage of 27.5% and 21.2%, respectively. No statistically significant correlations between Ki-67 and cleaved caspase-3 were observed within FMC. Conclusions and relevance A high proliferation index was found in feline mammary tumors. This is the first study evaluating cleaved caspase-3 expression in FMC.
- Publication
Journal of Feline Medicine & Surgery, 2017, Vol 19, Issue 4, p440
- ISSN
1098-612X
- Publication type
Article
- DOI
10.1177/1098612X16634150