We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Amyotrophe Lateralsklerose und frontotemporale Demenz – auf dem Weg zu gemeinsamen genspezifischen Therapieansätzen.
- Authors
Anderl-Straub, Sarah; Schuster, Joachim; Dorst, Johannes; Ludolph, Albert C.
- Abstract
Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share common neuropathological features and in the case of a gene mutation, also a genetic cause. To date five ALS-FTD genes are described in the literature in addition to other rare variants. Objective: The current state of research on treatment options for ALS and FTD is presented and an outlook on possible gene-specific approaches for ALS-FTD is provided. Material and methods: Analysis of the progression of ALS and FTD research by considering the increasing state of knowledge on the underlying pathomechanisms of the diseases. Results: In addition to anti-inflammatory approaches and stabilization of protein folding, promising gene-specific treatment approaches are currently being developed, which target common causes of ALS and FTD and therefore have an effect on both diseases. Conclusion: So far there are no causal treatment options for ALS and FTD. The increasing importance of genetic causes directs the focus to the development of gene-specific treatment.
- Subjects
PROTEIN folding; GENE therapy; THERAPEUTICS
- Publication
Der Nervenarzt, 2021, Vol 92, Issue 12, p1219
- ISSN
0028-2804
- Publication type
Article
- DOI
10.1007/s00115-021-01209-7